Stratum Corneum Anatomy - Cornified Envelope
Each corneocyte is enclosed by a macromolecule shell referred to as a cell envelope. The cell envelope consists primarily of 2 proteins, loricirn and involucrin. These proteins contain intensive links between one another creating the cell envelope the foremost insoluble structure of the corneocyte. the 2 sub-types of cell envelopes ar represented as "rigid" and "fragile" supported the interaction of lamellar bilayer with the cell envelope.
Attached to the cell envelope may be a layer of ceramide lipids that repel water. as a result of the lamellar lipoid bilayer additionally repels water, water molecules ar control between the cell envelope lipoids and therefore the lipid bilayer. This helps maintain the water balance within the corneum by tack water molecules rather than rental them absorb into the lower layers of the cuticle.
Stratum Corneum Anatomy - Corneodesmosomes
The "rivets" that hold the corneocytes along ar specialised supermolecule structures known as corneodesmosomes. These structures are a locality of the "mortar" within the "brick and mortar" analogy. Corneodesmosomes ar the foremost structure that has got to be degraded for the skin to shed during a method known as organic phenomenon.
Stratum Corneum Anatomy - Natural Moisturizing issue (NMF)
Natural moisturizing issue (NMF) may be a assortment of soluble compounds that ar solely found within the corneum. These compounds compose close to 20-30% of the dry weight of the corneocyte. NMF elements absorb water from the atmosphere and mix it with their own water content permitting the outer layers of the corneum to remain hydrous despite exposure to the weather. as a result of NMF elements ar water soluble, they're simply leached from the cells with water contact - that is why perennial contact with water truly makes the skin drier. The supermolecule layer encompassing the corneocyte helps seal the corneocyte to stop loss of NMF.
Stratum Corneum Anatomy - organic phenomenon method
The organic phenomenon, or exfoliation, method of the corneum is truly terribly advanced and solely components of this method ar absolutely understood. we tend to do grasp that many enzymes degrade the corneodesmosomes during a specific pattern, however we do not grasp the precise nature of those enzymes or however they become activated to begin the exfoliation method. we tend to do grasp that water and pH scale play a big role within the activity of those enzymes.
The "rivets" that hold the corneocytes along ar specialised supermolecule structures known as corneodesmosomes. These structures are a locality of the "mortar" within the "brick and mortar" analogy. Corneodesmosomes ar the foremost structure that has got to be degraded for the skin to shed during a method known as organic phenomenon.
Stratum Corneum Anatomy - Natural Moisturizing issue (NMF)
Natural moisturizing issue (NMF) may be a assortment of soluble compounds that ar solely found within the corneum. These compounds compose close to 20-30% of the dry weight of the corneocyte. NMF elements absorb water from the atmosphere and mix it with their own water content permitting the outer layers of the corneum to remain hydrous despite exposure to the weather. as a result of NMF elements ar water soluble, they're simply leached from the cells with water contact - that is why perennial contact with water truly makes the skin drier. The supermolecule layer encompassing the corneocyte helps seal the corneocyte to stop loss of NMF.
Stratum Corneum Anatomy - organic phenomenon method
The organic phenomenon, or exfoliation, method of the corneum is truly terribly advanced and solely components of this method ar absolutely understood. we tend to do grasp that many enzymes degrade the corneodesmosomes during a specific pattern, however we do not grasp the precise nature of those enzymes or however they become activated to begin the exfoliation method. we tend to do grasp that water and pH scale play a big role within the activity of those enzymes.
References
Ananthapadmanabhan, KP. "Cleansing without compromise: the impact of cleansers on the skin barrier and the technology of mild cleansing." Dermatologic Therapy. Vol 17. 2004: 17-25.
Ananthapadmanabhan, KP. "Cleansing without compromise: the impact of cleansers on the skin barrier and the technology of mild cleansing." Dermatologic Therapy. Vol 17. 2004: 17-25.
Harding, Clive. "The stratum corneum: structure and function in health and disease." Dermatologic Therapy. Vol 17. 2004: 6-15.
